INPP5E regulates phosphoinositide-dependent cilia transition zone function
Human ciliopathies, including Joubert syndrome (JBTS), arise from cilia dysfunction. The inositol polyphosphate 5-phosphatase INPP5E localizes to cilia and is mutated in JBTS. Murine Inpp5e ablation is embryonically lethal and recapitulates JBTS, including neural tube defects and polydactyly; howeve...
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| Hlavní autoři: | , , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | angličtina |
| Vydáno: |
2016
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| On-line přístup: | https://doi.org/10.1083/jcb.201511055 https://rupress.org/jcb/article-pdf/216/1/247/1373360/jcb_201511055.pdf |
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