A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth

A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth

Somatic mutations activating MAPK/PI3K signalling play a pivotal role in both tumours and brain developmental disorders. We developed a zebrafish model of brain tumour based on somatic expression of oncogenes that activate MAPK/PI3K signalling in neural progenitor cells. HRASV12 was the most effecti...

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Main Authors:	Marie Mayrhofer, Victor Gourain, Markus Reischl, Pierre Affaticati, Arnim Jenett, Jean‐Stéphane Joly, Matteo Benelli, Francesca Demichelis, Pietro Luigi Poliani, Dirk Sieger, Marina Mione
格式:	Artigo
语言:	英语
出版:	2016
在线阅读:	https://doi.org/10.1242/dmm.026500 http://dmm.biologists.org/content/dmm/10/1/15.full.pdf
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