A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth
Somatic mutations activating MAPK/PI3K signalling play a pivotal role in both tumours and brain developmental disorders. We developed a zebrafish model of brain tumour based on somatic expression of oncogenes that activate MAPK/PI3K signalling in neural progenitor cells. HRASV12 was the most effecti...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2016
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| Online Access: | https://doi.org/10.1242/dmm.026500 http://dmm.biologists.org/content/dmm/10/1/15.full.pdf |
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