SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) is caused by loss-of-function mutations in SEIPIN, a protein implicated in both adipogenesis and lipid droplet expansion but whose molecular function remains obscure. Here, we identify physical and functional interactions between SEIPIN and micros...

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Main Authors: Martin Pagac, Daniel E. Cooper, Yanfei Qi, Ivan Lukmantara, Hoi Yin Mak, Zengying Wu, Yuan Tian, Liu Z, Mona Lei, Ximing Du, Charles Ferguson, Damian P. Kotevski, Paweł Sadowski, Weiqin Chen, Salome Boroda, Thurl E. Harris, Chaojie Liu, Robert G. Parton, Xun Huang, Rosalind Coleman, Hongyuan Yang
Format: Artigo
Language:English
Published: 2016
Online Access:https://doi.org/10.1016/j.celrep.2016.10.037
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https://doi.org/10.1016/j.celrep.2016.10.037

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