Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla
Mutations in the isocitrate dehydrogenase enzyme are present in a majority of lower-grade gliomas and secondary glioblastomas. This mis-sense mutation results in the neomorphic reduction of isocitrate dehydrogenase resulting in an accumulation of the "oncometabolite" 2-hydroxyglutarate (2H...
Shranjeno v:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | angleščina |
| Izdano: |
2016
|
| Online dostop: | https://doi.org/10.1186/s12967-016-1035-1 https://translational-medicine.biomedcentral.com/track/pdf/10.1186/s12967-016-1035-1 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|
Komentirajte kot prvi!