The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn’s disease

Fibrosis is the result of dysregulated tissue regeneration and is characterized by excessive accumulation of matrix proteins that become detrimental to tissue function. In Crohn's disease, this manifests itself as recurrent gastrointestinal strictures for which there is no effective therapy bey...

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Príomhchruthaitheoirí: Bernard C. Lo, Matthew J. Gold, Michael R. Hughes, Frann Antignano, Yanet Valdez, Colby Zaph, Kenneth W. Harder, Kelly M. McNagny
Formáid: Artigo
Teanga:Béarla
Foilsithe / Cruthaithe: 2016
Rochtain ar líne:https://doi.org/10.1126/sciimmunol.aaf8864
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