Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

Highlights•HIV neutralizing antibodies were isolated from rabbits immunized with BG505 SOSIP.664•These antibodies target a hole in the glycan shield of BG505•Serum neutralization specificity maps to the same immunodominant glycan hole•Most HIV strains lack a conserved glycan site that could be a neu...

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Hlavní autoři: Laura E. McCoy, Marit J. van Gils, Gabriel Ozorowski, Terrence Messmer, Bryan Briney, James E. Voss, Daniel W. Kulp, Matthew S. Macauley, Devin Sok, Matthias Pauthner, Sergey Menis, Christopher A. Cottrell, Jonathan L. Torres, Jessica Hsueh, William R. Schief, Ian A. Wilson, Andrew B. Ward, Rogier W. Sanders, Dennis R. Burton
Médium: Artigo
Jazyk:angličtina
Vydáno: 2016
On-line přístup:https://doi.org/10.1016/j.celrep.2016.07.074
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https://doi.org/10.1016/j.celrep.2016.07.074

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