A chemical with proven clinical safety restores Down syndrome-related phenotypes via DYRK1A inhibition
DYRK1A is important in neuronal development and function, and its excessive activity is considered a significant pathogenic factor in Down syndrome and Alzheimer's disease. Thus, inhibition of DYRK1A has been suggested to be a new strategy to modify the disease. Very few compounds, however, hav...
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| Main Authors: | , , , , , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2016
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| 在线阅读: | https://doi.org/10.1242/dmm.025668 https://dmm.biologists.org/content/dmm/9/8/839.full.pdf |
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