Three-Dimensional Study of Alzheimer’s Disease Hallmarks Using the iDISCO Clearing Method
Amyloidosis is a major problem in over one hundred diseases, including Alzheimer's disease (AD). Using the iDISCO visualization method involving targeted molecular labeling, tissue clearing, and light-sheet microscopy, we studied plaque formation in the intact AD mouse brain at up to 27 months...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2016
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| 在線閱讀: | https://doi.org/10.1016/j.celrep.2016.06.060 https://www.cell.com/article/S2211124716308142/pdf |
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