<i>Plasmodium falciparum</i> Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes
MMV007564 is a novel antimalarial benzimidazolyl piperidine chemotype identified in cellular screens. To identify the genetic determinant of MMV007564 resistance, parasites were cultured in the presence of the compound to generate resistant lines. Whole genome sequencing revealed distinct mutations...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2016
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| 在线阅读: | https://doi.org/10.1021/acsinfecdis.6b00025 |
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