<i>Plasmodium falciparum</i> Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes

MMV007564 is a novel antimalarial benzimidazolyl piperidine chemotype identified in cellular screens. To identify the genetic determinant of MMV007564 resistance, parasites were cultured in the presence of the compound to generate resistant lines. Whole genome sequencing revealed distinct mutations...

Бүрэн тодорхойлолт

-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Pamela Magistrado, Victoria Corey, Amanda K. Lukens, Greg LaMonte, Erika Sasaki, Stephan Meister, Melanie Wree, Elizabeth A. Winzeler, Dyann F. Wirth
Формат: Artigo
Хэл сонгох:англи
Хэвлэсэн: 2016
Онлайн хандалт:https://doi.org/10.1021/acsinfecdis.6b00025
Шошгууд: Шошго нэмэх
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!