Covalent DNA–Protein Cross-Linking by Phosphoramide Mustard and Nornitrogen Mustard in Human Cells

N,N-Bis-(2-chloroethyl)-phosphorodiamidic acid (phosphoramide mustard, PM) and N,N-bis-(2-chloroethyl)-amine (nornitrogen mustard, NOR) are the two biologically active metabolites of cyclophosphamide, a DNA alkylating drug commonly used to treat lymphomas, breast cancer, certain brain cancers, and a...

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Principais autores: Arnold Groehler, Peter W. Villalta, Colin Campbell, Natalia Tretyakova
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Acesso em linha:https://doi.org/10.1021/acs.chemrestox.5b00430
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