Topologically associated domains enriched for lineage-specific genes reveal expression-dependent nuclear topologies during myogenesis

The linear distribution of genes across chromosomes and the spatial localization of genes within the nucleus are related to their transcriptional regulation. The mechanistic consequences of linear gene order, and how it may relate to the functional output of genome organization, remain to be fully r...

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Auteurs principaux: Daniel Neems, Arturo G. Garza-Gongora, Erica D. Smith, Steven T. Kosak
Format: Artigo
Langue:anglais
Publié: 2016
Accès en ligne:https://doi.org/10.1073/pnas.1521826113
https://www.pnas.org/content/pnas/113/12/E1691.full.pdf
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