An ankylosing spondylitis-associated genetic variant in the<i>IL23R-IL12RB2</i>intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

To explore the functional basis for the association between ankylosing spondylitis (AS) and single-nucleotide polymorphisms (SNPs) in the IL23R-IL12RB2 intergenic region. We performed conditional analysis on genetic association data and used epigenetic data on chromatin remodelling and transcription...

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Main Authors: Amity R. Roberts, Matteo Vecellio, Liye Chen, Anna Ridley, Adrián Cortés, Julian C. Knight, Paul Bowness, C. Cohen, B P Wordsworth
格式: Artigo
语言:英语
出版: 2016
在线阅读:https://doi.org/10.1136/annrheumdis-2015-208640
https://ard.bmj.com/content/annrheumdis/75/12/2150.full.pdf
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