Prediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods

Abstract The renal proximal tubule is a main target for drug-induced toxicity. The prediction of proximal tubular toxicity during drug development remains difficult. Any in vitro methods based on induced pluripotent stem cell-derived renal cells had not been developed, so far. Here, we developed a r...

Cur síos iomlán

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Karthikeyan Kandasamy, Jacqueline Kai Chin Chuah, Ran Su, Peng Huang, Kim Guan Eng, Sijing Xiong, Yao Li, Chun Siang Chia, Lit‐Hsin Loo, Daniele Zink
Formáid: Artigo
Teanga:Béarla
Foilsithe / Cruthaithe: 2015
Rochtain ar líne:https://doi.org/10.1038/srep12337
https://www.nature.com/articles/srep12337.pdf
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