Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

We have created early-onset transgenic (Tg) models by exploiting the synergistic effects of familial Alzheimer's disease mutations on amyloid β-peptide (Aβ) biogenesis. TgCRND8 mice encode a double mutant form of amyloid precursor protein 695 (KM670/671NL+V717F) under the control of the PrP gen...

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Main Authors: M. Azhar Chishti, Dun-Shen Yang, Christopher Janus, Amie L. Phinney, Patrick Horne, Jacqueline Pearson, Robert Strome, Noah B. Zuker, James Loukides, Jacqueline A. French, Sherry Turner, Gianluca Lozza, Mariagrazia Grilli, Suzanne Kunicki, Céline Morissette, Julie Paquette, Francine Gervais, Catherine Bergeron, Paul E. Fraser, George A. Carlson, Peter St George‐Hyslop, David Westaway
Format: Artigo
Language:English
Published: 2001
Online Access:https://doi.org/10.1074/jbc.m100710200
http://www.jbc.org/article/S0021925820787296/pdf
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https://doi.org/10.1074/jbc.m100710200
http://www.jbc.org/article/S0021925820787296/pdf

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