Insulin Prevents Cardiomyocytes From Oxidative Stress–Induced Apoptosis Through Activation of PI3 Kinase/ <i>Akt</i>

Background —Loss of cardiomyocytes by apoptosis is proposed to cause heart failure. Reactive oxygen species induce apoptosis in many types of cells including cardiomyocytes. Because insulin has been reported to have protective effects, we examined whether insulin prevents cardiomyocytes from oxidati...

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Bibliographic Details
Main Authors: Ryuichi Aikawa, Masao Nawano, Yaping Gu, Hideki Katagiri, Tomoichiro Asano, Weidong Zhu, Ryozo Nagai, Issei Komuro
Format: Artigo
Language:English
Published: 2000
Online Access:https://doi.org/10.1161/01.cir.102.23.2873
https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.102.23.2873
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