Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.
Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be causal events for the majority of spontaneous clear-cell renal carcinomas. We now show that hypermethylation of a normally unmethylated CpG island in the 5' region provides another potentially important me...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Language: | English |
| Published: |
1994
|
| Online Access: | https://doi.org/10.1073/pnas.91.21.9700 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|