Analysis of Uromodulin Polymerization Provides New Insights into the Mechanisms Regulating ZP Domain-mediated Protein Assembly
Uromodulin is the most abundant protein secreted in urine, in which it is found as a high-molecular-weight polymer. Polymerization occurs via its zona pellucida (ZP) domain, a conserved module shared by many extracellular eukaryotic proteins that are able to assemble into matrices. In this work, we...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2008
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| Online Access: | https://doi.org/10.1091/mbc.e08-08-0876 |
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