Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation

VE-cadherin-mediated cell-cell junction weakening increases paracellular permeability in response to both angiogenic and inflammatory stimuli. Although Semaphorin 3A has emerged as one of the few known anti-angiogenic factors to exhibit pro-permeability activity, little is known about how it trigger...

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Main Authors: Armelle Le Guelte, Eva María Galán‐Moya, Julie Dwyer, Lucas Treps, Garance Kettler, Jagoda K. Hebda, Sonia M. Dubois, Cédric Auffray, Hervé Chneiweiss, Nicolas Bidère, Julie Gavard
Format: Artigo
Language:English
Published: 2012
Online Access:https://doi.org/10.1242/jcs.108282
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