Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor

Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor

Indinavir (IDV) (also called CRIXIVAN, MK-639, or L-735,524) is a potent and selective inhibitor of the human immunodeficiency virus type 1 (HIV-1) protease. During early clinical trials, in which patients initiated therapy with suboptimal dosages of IDV, we monitored the emergence of viral resistan...

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Hlavní autoři: Jon H. Condra, Daniel Holder, William A. Schleif, O M Blahy, Robert M. Danovich, Lori J. Gabryelski, Donald J. Graham, Dale W. Laird, J C Quintero, Audrey Rhodes, Helen L. Robbins, E. Jill Roth, Shivaprakash M. Rudramurthy, Tao Yang, J Chodakewitz, Paul Deutsch, Randi Y. Leavitt, F Massari, John W. Mellors, K. Squires, Roy T. Steigbigel, Hedy Teppler, Emilio A. Emini
Médium: Artigo
Jazyk:angličtina
Vydáno: 1996
On-line přístup:https://doi.org/10.1128/jvi.70.12.8270-8276.1996
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https://doi.org/10.1128/jvi.70.12.8270-8276.1996

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