In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I
OBJECTIVE The activation of AMP-activated protein kinase (AMPK) has been reported to improve endothelial function. However, the targets of AMPK in endothelial cells remain poorly defined. The aim of this study was to test whether AMPK suppresses the degradation of GTP-cyclohydrolase (GTPCH I), a key...
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主要な著者: | , , , , |
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フォーマット: | Artigo |
言語: | 英語 |
出版事項: |
2009
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オンライン・アクセス: | https://doi.org/10.2337/db09-0267 https://diabetesjournals.org/diabetes/article-pdf/58/8/1893/663366/zdb00809001893.pdf |
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