In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I

OBJECTIVE The activation of AMP-activated protein kinase (AMPK) has been reported to improve endothelial function. However, the targets of AMPK in endothelial cells remain poorly defined. The aim of this study was to test whether AMPK suppresses the degradation of GTP-cyclohydrolase (GTPCH I), a key...

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主要な著者: Shuangxi Wang, Jian Xu, Ping Song, Benoı̂t Viollet, Ming‐Hui Zou
フォーマット: Artigo
言語:英語
出版事項: 2009
オンライン・アクセス:https://doi.org/10.2337/db09-0267
https://diabetesjournals.org/diabetes/article-pdf/58/8/1893/663366/zdb00809001893.pdf
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