In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I

OBJECTIVE The activation of AMP-activated protein kinase (AMPK) has been reported to improve endothelial function. However, the targets of AMPK in endothelial cells remain poorly defined. The aim of this study was to test whether AMPK suppresses the degradation of GTP-cyclohydrolase (GTPCH I), a key...

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Bibliografiske detaljer
Main Authors: Shuangxi Wang, Jian Xu, Ping Song, Benoı̂t Viollet, Ming‐Hui Zou
Format: Artigo
Sprog:engelsk
Udgivet: 2009
Online adgang:https://doi.org/10.2337/db09-0267
https://diabetesjournals.org/diabetes/article-pdf/58/8/1893/663366/zdb00809001893.pdf
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