Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene <i>mps1</i>
Aneuploidy, resulting from chromosome missegregation during meiosis, is a major cause of human infertility and birth defects. However, its molecular basis remains incompletely understood. Here we have identified a spectrum of chromosome anomalies in embryos of zebrafish homozygous for a hypomorphic...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | engelsk |
| Udgivet: |
2004
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| Online adgang: | https://doi.org/10.1101/gad.1182604 http://genesdev.cshlp.org/content/18/13/1527.full.pdf |
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| Summary: | Aneuploidy, resulting from chromosome missegregation during meiosis, is a major cause of human infertility and birth defects. However, its molecular basis remains incompletely understood. Here we have identified a spectrum of chromosome anomalies in embryos of zebrafish homozygous for a hypomorphic mutation in Mps1, a kinase required for the mitotic checkpoint. These aneuploidies are caused by meiotic error and result in severe developmental defects. Our results reveal Mps1 as a critical regulator of chromosome number in zebrafish, and demonstrate how slight genetic perturbation of a mitotic checkpoint factor can dramatically reduce the fidelity of chromosome segregation during vertebrate meiosis. |
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