Regulation of dendritic cell activation by microRNA let-7c and BLIMP1

Mice with a DC-specific deletion of the transcriptional repressor B lymphocyte–induced maturation protein-1 (Blimp1) exhibit a lupus-like phenotype, secondary to enhanced DC production of IL-6. Here we explored further phenotypic changes in Blimp1-deficient DCs, the molecular mechanism underlying th...

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Main Authors: Sun Jung Kim, Peter K. Gregersen, Betty Diamond
Formato: Artigo
Idioma:inglés
Publicado: 2013
Acceso en liña:https://doi.org/10.1172/jci64712
http://www.jci.org/articles/view/64712/files/pdf
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