A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice
In a phenotype-driven mutagenesis screen, a novel, dominant mouse mutation, Nmf350, caused low seizure threshold, sporadic tonic–clonic seizures, brain enlargement and ectopic neurons in the dentate hilus and molecular layer of the hippocampus. Genetic mapping implicated Akt3, one of four candidates...
Enregistré dans:
| Auteurs principaux: | , , , , , , |
|---|---|
| Format: | Artigo |
| Langue: | anglais |
| Publié: |
2010
|
| Accès en ligne: | https://doi.org/10.1093/hmg/ddq544 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|