Gene Expression Patterns in Mismatch Repair-Deficient Colorectal Cancers Highlight the Potential Therapeutic Role of Inhibitors of the Phosphatidylinositol 3-Kinase-AKT-Mammalian Target of Rapamycin Pathway

Gene Expression Patterns in Mismatch Repair-Deficient Colorectal Cancers Highlight the Potential Therapeutic Role of Inhibitors of the Phosphatidylinositol 3-Kinase-AKT-Mammalian Target of Rapamycin Pathway

High-frequency microsatellite-instable (MSI-H) tumors account for approximately 15% of colorectal cancers. Therapeutic decisions for colorectal cancer are empirically based and currently do not emphasize molecular subclassification despite an increasing collection of gene expression information. Our...

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Hlavní autoři: Eduardo Vilar, Bhramar Mukherjee, Rork Kuick, Leon Raskin, David E. Misek, Jeremy M. G. Taylor, Thomas J. Giordano, Samir Hanash, Eric R. Fearon, Gad Rennert, Stephen B. Gruber
Médium: Artigo
Jazyk:angličtina
Vydáno: 2009
On-line přístup:https://doi.org/10.1158/1078-0432.ccr-08-2432
https://clincancerres.aacrjournals.org/content/clincanres/15/8/2829.full.pdf
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https://doi.org/10.1158/1078-0432.ccr-08-2432
https://clincancerres.aacrjournals.org/content/clincanres/15/8/2829.full.pdf

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