CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris

CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris

Engagement of the B7 family of molecules on antigen-presenting cells with their T cell–associated ligands, CD28 and CD152 (cytotoxic T lymphocyte–associated antigen-4 [CTLA-4]), provides a pivotal costimulatory signal in T-cell activation. We investigated the role of the CD28/CD152 pathway in psoria...

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Main Authors: Judith R. Abrams, Mark Lebwohl, Cynthia Guzzo, Brian V. Jegasothy, Michael Goldfarb, Bernard S. Goffe, Alan Menter, Nicholas J. Lowe, Gerald G. Krueger, Michael J. Brown, Russell Weiner, Martin Birkhofer, Garvin L. Warner, Karen Berry, Peter S. Linsley, James G. Krueger, Hans D. Ochs, Susan L. Kelley, Sewon Kang
Format: Artigo
Language:English
Published: 1999
Online Access:https://doi.org/10.1172/jci5857
http://www.jci.org/articles/view/5857/files/pdf
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https://doi.org/10.1172/jci5857
http://www.jci.org/articles/view/5857/files/pdf

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