Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes
We evaluated the prevalence of endothelial dysfunction as measured by flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (c-IMT) in relationship to vascular inflammatory biomarkers in preadolescent children with type 1 diabetes.We studied 21 type 1 diabetic chil...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
2011
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| Online Erişim: | https://doi.org/10.2337/dc10-2134 https://diabetesjournals.org/care/article-pdf/34/3/681/611215/681.pdf |
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| _version_ | 1838650285997686784 |
|---|---|
| access_facet | Acesso Aberto |
| author | Ghufran Babar Hanaa Zidan Michael E. Widlansky Emon Das Raymond G. Hoffmann Marwan Daoud Ramin Alemzadeh |
| author_facet | Ghufran Babar Hanaa Zidan Michael E. Widlansky Emon Das Raymond G. Hoffmann Marwan Daoud Ramin Alemzadeh |
| cited_by_count_is | 83 |
| collection | OpenAlex |
| description | We evaluated the prevalence of endothelial dysfunction as measured by flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (c-IMT) in relationship to vascular inflammatory biomarkers in preadolescent children with type 1 diabetes.We studied 21 type 1 diabetic children (aged 8.3 ± 0.3 years with diabetes duration of 4.3 ± 0.4 years) and 15 group-matched healthy siblings (aged 7.6 ± 0.3 years). Fasting plasma glucose (FPG), lipid profile, HbA(1c), high-sensitivity C-reactive protein (hs-CRP), fibrinogen, homocysteine, and erythrocyte (red blood cell [RBC]) folate were evaluated in all subjects. Each subject underwent c-IMT and brachial artery FMD percentage (FMD%) measurements using high-resolution vascular ultrasound.Type 1 diabetic children had higher FPG (173.4 ± 7.9 mg/dL vs. 81.40 ± 1.7 mg/dL; P < 0.0001), HbA(1c) (8.0 ± 0.2% vs. 5.0 ± 0.1%; P < 0.0001), and hs-CRP (1.8 ± 0.3 vs. 0.70 ± 0.2; P = 0.017) than control children without significant differences in BMI, homocysteine, and fibrinogen levels; RBC folate content; and c-IMT between the groups. Children with type 1 diabetes had lower FMD% than control children (7.1 ± 0.8% vs. 9.8 ± 1.1%; P = 0.04), whereas c-IMT did not differ between groups.Preadolescent children with type 1 diabetes and mean diabetes duration of 4 years displayed evidence of low-intensity vascular inflammation and attenuated FMD measurements. These data suggest that endothelial dysfunction and systemic inflammation, known harbingers of future cardiovascular risk, are present even in preadolescent children. |
| format | Artigo |
| frbr_group_id_str | doi-10.2337/dc10-2134 |
| id | openalex-W2136125087 |
| institution | Children's Mercy Hospital |
| issn_str | 0149-5992 |
| issue_str | 3 |
| journal_title_str | Diabetes Care |
| language | eng |
| publishDate | 2011 |
| publisher_str | American Diabetes Association |
| spellingShingle | Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes Ghufran Babar Hanaa Zidan Michael E. Widlansky Emon Das Raymond G. Hoffmann Marwan Daoud Ramin Alemzadeh |
| title | Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes |
| title_full | Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes |
| title_fullStr | Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes |
| title_full_unstemmed | Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes |
| title_short | Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes |
| topic_facet | Medicine Internal medicine Brachial artery Homocysteine Diabetes mellitus Endothelial dysfunction Endocrinology Type 2 diabetes Fibrinogen Type 1 diabetes C-reactive protein Intima-media thickness Inflammation Carotid arteries Blood pressure |
| url | https://doi.org/10.2337/dc10-2134 https://diabetesjournals.org/care/article-pdf/34/3/681/611215/681.pdf |
| volume_str | 34 |