Sinoatrial Node Pacemaker Activity Requires Ca <sup>2+</sup> /Calmodulin-Dependent Protein Kinase II Activation
Cardiac beating arises from the spontaneous rhythmic excitation of sinoatrial (SA) node cells. Here we report that SA node pacemaker activity is critically dependent on Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). In freshly dissociated rabbit single SA node cells, inhibition of CaMKII by...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2000
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| Online Access: | https://doi.org/10.1161/01.res.87.9.760 |
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