Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow
The NMDA receptor (R) plays important roles in brain physiology and pathology as an ion channel. Here we examine the ion flow-independent coupling of agonist to the NMDAR cytoplasmic domain (cd). We measure FRET between fluorescently tagged cytoplasmic domains of GluN1 subunits of NMDARs expressed i...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2015
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| 在线阅读: | https://doi.org/10.1073/pnas.1520023112 https://www.pnas.org/content/pnas/112/47/14705.full.pdf |
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