Loss of Tumor Suppressor RPL5/RPL11 Does Not Induce Cell Cycle Arrest but Impedes Proliferation Due to Reduced Ribosome Content and Translation Capacity
Humans have evolved elaborate mechanisms to activate p53 in response to insults that lead to cancer, including the binding and inhibition of Hdm2 by the 60S ribosomal proteins (RPs) RPL5 and RPL11. This same mechanism appears to be activated upon impaired ribosome biogenesis, a risk factor for cance...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2013
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| Online Access: | https://doi.org/10.1128/mcb.01174-13 https://mcb.asm.org/content/mcb/33/23/4660.full.pdf |
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