Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

Alzheimer's disease (AD) is a severe age-related neurodegenerative disorder characterized by accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline. Several genes have been implicated in AD, but chromatin state alterations during neurode...

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Main Authors: Elizabeta Gjoneska, Andreas Pfenning, Hansruedi Mathys, Gerald Quon, Anshul Kundaje, Li-Huei Tsai, Manolis Kellis
格式: Artigo
语言:英语
出版: 2015
在线阅读:https://doi.org/10.1038/nature14252
https://www.nature.com/articles/nature14252.pdf
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