New (alternative) temozolomide regimens for the treatment of glioma
One barrier to successful treatment of malignant glioma is resistance to alkylating agents such as temozolomide. The cytotoxic activity of temozolomide and other alkylating agents is believed to manifest largely by the formation of O(6)-methylguanine DNA adducts. Consequently, the primary mechanism...
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| Main Authors: | , , |
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| 格式: | Revisão |
| 语言: | 英语 |
| 出版: |
2008
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| 在线阅读: | https://doi.org/10.1215/15228517-2008-078 |
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