NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets
We take a functional genomics approach to congenital heart disease mechanism. We used DamID to establish a robust set of target genes for NKX2-5 wild type and disease associated NKX2-5 mutations to model loss-of-function in gene regulatory networks. NKX2-5 mutants, including those with a crippled ho...
Shranjeno v:
Main Authors: | , , , , , , , , , , , , , , , , , |
---|---|
Format: | Artigo |
Jezik: | angleščina |
Izdano: |
2015
|
Online dostop: | https://doi.org/10.7554/elife.06942 |
Oznake: |
Označite
Brez oznak, prvi označite!
|
Komentirajte kot prvi!