Targeting Akt and Heat Shock Protein 90 Produces Synergistic Multiple Myeloma Cell Cytotoxicity in the Bone Marrow Microenvironment

Abstract Purpose: We hypothesized that targeting both Akt and heat shock protein (HSP) 90 would induce cytotoxic activity against multiple myeloma (MM) cells and target the bone marrow (BM) microenvironment to inhibit angiogenesis, osteoclast formation, as well as migration and adhesion of MM cells....

وصف كامل

محفوظ في:

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Alissa Huston, Xavier Leleu, Xiaoying Jia, Anne-Sophie Moreau, Hai T. Ngo, Judith Runnels, Judy Anderson, Yazan Alsayed, Aldo M. Roccaro, Sonia Vallet, Evdoxia Hatjiharissi, Yu-Tsu Tai, Peter Sportelli, Nikhil C. Munshi, Paul G. Richardson, Teru Hideshima, David Roodman, Kenneth C. Anderson, Irene M. Ghobrial
التنسيق:	Artigo
اللغة:	الإنجليزية
منشور في:	2008
الوصول للمادة أونلاين:	https://doi.org/10.1158/1078-0432.ccr-07-1299 https://aacrjournals.org/clincancerres/article-pdf/14/3/865/1979022/865.pdf
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

الانترنت

https://doi.org/10.1158/1078-0432.ccr-07-1299
https://aacrjournals.org/clincancerres/article-pdf/14/3/865/1979022/865.pdf

Targeting Akt and Heat Shock Protein 90 Produces Synergistic Multiple Myeloma Cell Cytotoxicity in the Bone Marrow Microenvironment

الانترنت

مواد مشابهة