Targeting Akt and Heat Shock Protein 90 Produces Synergistic Multiple Myeloma Cell Cytotoxicity in the Bone Marrow Microenvironment

Targeting Akt and Heat Shock Protein 90 Produces Synergistic Multiple Myeloma Cell Cytotoxicity in the Bone Marrow Microenvironment

Abstract Purpose: We hypothesized that targeting both Akt and heat shock protein (HSP) 90 would induce cytotoxic activity against multiple myeloma (MM) cells and target the bone marrow (BM) microenvironment to inhibit angiogenesis, osteoclast formation, as well as migration and adhesion of MM cells....

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Autori principali:	Alissa Huston, Xavier Leleu, Xiaoying Jia, Anne-Sophie Moreau, Hai T. Ngo, Judith Runnels, Judy Anderson, Yazan Alsayed, Aldo M. Roccaro, Sonia Vallet, Evdoxia Hatjiharissi, Yu-Tsu Tai, Peter Sportelli, Nikhil C. Munshi, Paul G. Richardson, Teru Hideshima, David Roodman, Kenneth C. Anderson, Irene M. Ghobrial
Natura:	Artigo
Lingua:	inglese
Pubblicazione:	2008
Accesso online:	https://doi.org/10.1158/1078-0432.ccr-07-1299 https://aacrjournals.org/clincancerres/article-pdf/14/3/865/1979022/865.pdf
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