De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

A small number of rare, recurrent genomic copy number variants (CNVs) are known to substantially increase susceptibility to schizophrenia. As a consequence of the low fecundity in people with schizophrenia and other neurodevelopmental phenotypes to which these CNVs contribute, CNVs with large effect...

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Bibliografiset tiedot
Päätekijät: George Kirov, Andrew Pocklington, Peter Holmans, Dobril Ivanov, Masashi Ikeda, Douglas M. Ruderfer, Jennifer L. Moran, Kimberly Chambert, Драга Тончева, L. Georgieva, Detelina Grozeva, Marija Fjodorova, R Wollerton, Elliott Rees, Ivan Nikolov, Louie N. van de Lagemaat, Àlex Bayés, E Fernández, Pall I. Olason, Yvonne Böttcher, Noboru H. Komiyama, Mark O. Collins, Jyoti S. Choudhary, Kāri Stefánsson, Hreinn Stefánsson, Seth G. N. Grant, Shaun Purcell, Pamela Sklar, Michael O’Donovan, Michael J. Owen
Aineistotyyppi: Artigo
Kieli:englanti
Julkaistu: 2011
Linkit:https://doi.org/10.1038/mp.2011.154
https://www.nature.com/articles/mp2011154.pdf
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Internet

https://doi.org/10.1038/mp.2011.154
https://www.nature.com/articles/mp2011154.pdf

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