Dosage Compensation in the Mouse Balances Up-Regulation and Silencing of X-Linked Genes
Dosage compensation in mammals involves silencing of one X chromosome in XX females and requires expression, in cis, of Xist RNA. The X to be inactivated is randomly chosen in cells of the inner cell mass (ICM) at the blastocyst stage of development. Embryonic stem (ES) cells derived from the ICM of...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2007
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| Online Access: | https://doi.org/10.1371/journal.pbio.0050326 https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0050326&type=printable |
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