Self‐reported sleep disturbance is associated with Alzheimer's disease risk in men
To study the association between self-reported sleep disturbances and dementia risk.Self-reported sleep disturbances and established risk factors for dementia were measured in men at ages 50 (n = 1574) and 70 (n = 1029) years. Dementia incidence was determined by reviewing their patient history betw...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2014
|
| 在線閱讀: | https://doi.org/10.1016/j.jalz.2014.08.104 https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2014.08.104 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|
| 總結: | To study the association between self-reported sleep disturbances and dementia risk.Self-reported sleep disturbances and established risk factors for dementia were measured in men at ages 50 (n = 1574) and 70 (n = 1029) years. Dementia incidence was determined by reviewing their patient history between ages 50 and 90 years. In addition, plasma levels of β-amyloid (Aβ) peptides 1-40 and 1-42 were measured at ages 70, 77, and 82 years.Cox regression demonstrated that men with self-reported sleep disturbances had a higher risk of developing dementia (+33%) and Alzheimer's disease (AD, +51%) than men without self-reported sleep disturbances (both P < .05). Binary logistic regression showed the increased risk for both dementia (+114%) and AD (+192%) were highest when sleep disturbance was reported at age 70 years (both P < .001). No group differences were found in Aβ levels.Improving sleep quality may help reduce the neurodegenerative risk in older men. |
|---|