ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis
Mammals have two genes encoding homologues of the endoplasmic reticulum (ER) disulfide oxidase ERO1 (ER oxidoreductin 1). ERO1-β is greatly enriched in the endocrine pancreas. We report in this study that homozygosity for a disrupting allele of Ero1lb selectively compromises oxidative folding of pro...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2010
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| 在線閱讀: | https://doi.org/10.1083/jcb.200911086 https://rupress.org/jcb/article-pdf/188/6/821/1346279/jcb_200911086.pdf |
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