Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by <i>EML4-ALK</i> Fusion Oncogene

Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by <i>EML4-ALK</i> Fusion Oncogene

Genetic rearrangements of the anaplastic lymphoma kinase (ALK) kinase occur in 3% to 13% of non-small cell lung cancer patients and rarely coexist with KRASor EGFR mutations. To evaluate potential treatment strategies for lung cancers driven by an activated EML4-ALK chimeric oncogene, we generated a...

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Main Authors: Zhao Chen, Takaaki Sasaki, Xiaohong Tan, Julián Carretero, Takeshi Shimamura, Danan Li, Chunxiao Xu, Yuchuan Wang, Guillaume Adelmant, Marzia Capelletti, Hyun Joo Lee, Scott J. Rodig, Christa L. Borgman, Seung-Il Park, Hyeong Ryul Kim, Robert F. Padera, Jarrod A. Marto, Nathanael S. Gray, Andrew L. Kung, Geoffrey I. Shapiro, Pasi A. Jänne, Kwok‐Kin Wong
Format: Artigo
Language:English
Published: 2010
Online Access:https://doi.org/10.1158/0008-5472.can-10-1671
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https://doi.org/10.1158/0008-5472.can-10-1671

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