A Mixture of Functionally Oligoclonal Humanized Monoclonal Antibodies That Neutralize Clostridium difficile TcdA and TcdB with High Levels of<i>In Vitro</i>Potency Shows<i>In Vivo</i>Protection in a Hamster Infection Model

A Mixture of Functionally Oligoclonal Humanized Monoclonal Antibodies That Neutralize Clostridium difficile TcdA and TcdB with High Levels of<i>In Vitro</i>Potency Shows<i>In Vivo</i>Protection in a Hamster Infection Model

Clostridium difficile infections are a major cause of antibiotic-associated diarrhea in hospital and care facility patients. In spite of the availability of effective antibiotic treatments, C. difficile infection (CDI) is still a major cause of patient suffering, death, and substantial health care c...

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Main Authors: Nicola L. Davies, Joanne Compson, Brendon MacKenzie, Victoria O’Dowd, Amanda Oxbrow, James T. Heads, Alison Turner, Kaushik Sarkar, Sarah Dugdale, Mark Jairaj, Louis Christodoulou, David Knight, Amanda S. Cross, Karine Hervé, Kerry Tyson, Hanna Hailu, Carl Doyle, Mark Ellis, Marco Kriek, Matthew Cox, Matthew Page, Adrian Moore, Daniel Lightwood, David P. Humphreys
Format: Artigo
Language:English
Published: 2013
Online Access:https://doi.org/10.1128/cvi.00625-12
https://cvi.asm.org/content/cdli/20/3/377.full.pdf
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https://doi.org/10.1128/cvi.00625-12
https://cvi.asm.org/content/cdli/20/3/377.full.pdf

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