Preclinical Differentiation between Apparently Safe and Potentially Hepatotoxic Applications of TRAIL Either Alone or in Combination with Chemotherapeutic Drugs
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) exhibits potent antitumor activity on systemic administration in nonhuman primates without deleterious side effects for normal tissue. However, there is a controversy about the potential toxicity of TRAIL on human hepatocytes. The...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2006
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| 在線閱讀: | https://doi.org/10.1158/1078-0432.ccr-05-2635 https://aacrjournals.org/clincancerres/article-pdf/12/8/2640/1968793/2640.pdf |
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