Molecular Basis of Prodrug Activation by Human Valacyclovirase, an α-Amino Acid Ester Hydrolase
Chemical modification to improve biopharmaceutical properties, especially oral absorption and bioavailability, is a common strategy employed by pharmaceutical chemists. The approach often employs a simple structural modification and utilizes ubiquitous endogenous esterases as activation enzymes, alt...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2008
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| 在线阅读: | https://doi.org/10.1074/jbc.m709530200 http://www.jbc.org/article/S0021925820528986/pdf |
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