Constructing RNA dynamical ensembles by combining MD and motionally decoupled NMR RDCs: new insights into RNA dynamics and adaptive ligand recognition
We describe a strategy for constructing atomic resolution dynamical ensembles of RNA molecules, spanning up to millisecond timescales, that combines molecular dynamics (MD) simulations with NMR residual dipolar couplings (RDC) measured in elongated RNA. The ensembles are generated via a Monte Carlo...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | angličtina |
| Vydáno: |
2009
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| On-line přístup: | https://doi.org/10.1093/nar/gkp156 https://academic.oup.com/nar/article-pdf/37/11/3670/16751880/gkp156.pdf |
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