Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

During infection and tissue damage, virulence factors and alarmins are pro-inflammatory and induce activation of various immune cells including macrophages and mast cells (MCs). Activated MCs instantly release preformed inflammatory mediators, including several proteases. The chymase mouse mast cell...

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Bibliographic Details
Main Authors: Ananya Roy, Goutham Ganesh, Helena Sippola, Sara Bolin, Osama Sawesi, Anders Dagälv, Susan Schlenner, Thorsten B. Feyerabend, Hans-Reimer Rodewald, Lena Kjellén, Lars Hellman, Magnus Åbrink
Format: Artigo
Language:English
Published: 2013
Online Access:https://doi.org/10.1074/jbc.m112.435156
http://www.jbc.org/article/S0021925820416084/pdf
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https://doi.org/10.1074/jbc.m112.435156
http://www.jbc.org/article/S0021925820416084/pdf

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