Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition
Significance The aggregation of mutant proteins is pathologically implicated in a large number of neuropathies, including Huntington disease and ALS. Although the appearance of protein aggregates is known to sequester other proteins, how this results in the gain-of-function toxicity in these disease...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2014
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| 在线阅读: | https://doi.org/10.1073/pnas.1321811111 |
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