Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition
Significance The aggregation of mutant proteins is pathologically implicated in a large number of neuropathies, including Huntington disease and ALS. Although the appearance of protein aggregates is known to sequester other proteins, how this results in the gain-of-function toxicity in these disease...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , , |
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| التنسيق: | Artigo |
| اللغة: | الإنجليزية |
| منشور في: |
2014
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| الوصول للمادة أونلاين: | https://doi.org/10.1073/pnas.1321811111 |
| الوسوم: |
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