Up-regulation of COX-2/PGE2 by endothelin-1 via MAPK-dependent NF-κB pathway in mouse brain microvascular endothelial cells
Endothelin-1 (ET-1) is a proinflammatory mediator and elevated in the regions of several brain injury and inflammatory diseases. The deleterious effects of ET-1 on endothelial cells may aggravate brain inflammation mediated through the regulation of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) s...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2013
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| 在线阅读: | https://doi.org/10.1186/1478-811x-11-8 https://biosignaling.biomedcentral.com/counter/pdf/10.1186/1478-811X-11-8 |
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